Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease

Lysophosphatidic acid (LPA) is an endogenous lysophospholipid and a bioactive lipid that synthesized by the enzyme autotaxin (ATX). The ATX–LPA axis has been associated with cognitive dysfunction inflammatory diseases, mainly in range of nonalcoholic liver diseases. Recently, preclinical clinical evidence suggested role LPA signaling alcohol use disorder (AUD) AUD-related function. However, not sufficiently investigated alcoholic An exploratory study was conducted 136 participants, 66 abstinent patients AUD seeking treatment for (alcohol group), 70 healthy control subjects (control group). group divided according to presence comorbid diseases (i.e., fatty liver/steatosis, steatohepatitis, or cirrhosis). All participants were clinically evaluated, plasma concentrations total ATX measured using enzyme-linked immunosorbent assays. Data primarily analyzed analysis covariance (ANCOVA) while controlling age, body mass index, sex. Logistic regression models created assess association disease. log10-transformed fit assumptions parametric testing.The main results as follows: dysregulated group, had significantly lower (F(1,131) = 10.677, p 0.001) higher 8.327, 0.005) than subjects; disease (post hoc test, < 0.05) but disease; significant correlations between variables only found non-liver subgroup (the duration abstinence (r +0.33, 0.05); severity (rho −0.33, 0.05)); logistic model LPA, ATX, showed excellent discriminative power (area under curve (AUC) 0.915, distinguishing In conclusion, our data show suggest this signaling, combination relevant variables, reliable biomarker